Alprazolam is well known by its brand name Xanax. This is an FDA-approved medication that is used to manage panic disorder and anxiety. The tablet has an advanced composition which includes the active ingredient alprazolam. Alprazolam produces a calming effect on the brain which helps patients overcome bouts of anxiety and panic.
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Alprazolam was patented in 1971 and approved for medical use in the United States in 1981, and marketed as Xanax in the same year by Upjohn Laboratories which later become a part of Pfizer. At the time, the medication was the first approved treatment for panic attacks and it rapidly became a popular anxiety medication due to its effectiveness, and it destigmatized a mental health disorder into an ailment that can be easily treated with a short course of tablets.
Xanax is by far the most well-known brand name for alprazolam in the UK, but there are numerous other brand names such as Alprox, Alpraz, Cassadan, and Ralozam.
This medicine is one of a family of pharmaceuticals known as benzodiazepines (BZDs), but is a little different because it is classed as a triazolobenzodiazepine (TBZD), making it a short-acting tranquilizer. This does not mean that the effects of TBZDs are faster acting than standard BZDs, but they do stay active in the body for a shorter period of time.
The pharmacological structure and composition enable it to tackle both moderate and severe levels of panic and anxiety. Studies have reported and confirmed that the tablet provides effective relief from anxiety when many other options fail.
Since it was first released on to the market, this medication quickly became the go-to medicine for doctors treating anxiety disorders, and in 2017, it was prescribed more than 25 million times.
Fortunately, people no longer need to be reliant on expensive branded medications, as there are now cheaper generic treatments available online. Alprazolam tablets contain active ingredients that are 100% identical to the branded anxiety medications.
Alprazolam works by boosting gamma-aminobutyric acid (GABA), which is a neurotransmitter in the brain that induces a feeling of calmness. It is generally used for the short-term management of anxiety disorders, specifically panic disorder or generalized anxiety disorder (GAD)
The unique chemical composition of this tablet has been developed to treat the symptoms that come with anxiety disorders such as:
Millions of users over the years have been found its sedative effect on the Central Nervous System highly beneficial, and help manage anxiety and panic disorders, because this anti-anxiety medication helps patients to relax and calm down, which reduces stress and irrational thoughts.
Alprazolam can also be used to reduce and treat the nausea that is experienced after chemotherapy, and the anxiety conditions which can arise during cancer treatment.
Xanax side effects are rare and usually occur when instructions and precautions are not followed. If side effects are experienced, they are mild, and can be treated or disappear on their own.
Clinical studies have shown that the benefits of this anti-anxiety treatment are far greater than the mild side effects. In general, these studies confirmed that this treatment caused very few problems for patients, and side effects that were noticed did not last long, and tended to quickly disappear.
The Xanax side effects listed below are not experienced by everyone who take this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
Common Xanax side effects include:
Do not take opioids, such as tramadol or codeine with this medication. When used together, these drugs can cause dangerous effects in the body, and increases the risk for severe sleepiness, respiratory depression, coma, and even death.
When alcohol is taken in combination with alprazolam, they have a doubling effect on one another. They may decrease the benefits and increase the adverse effects of the medication. It will take longer to clear this medicine from the body, and combining alcohol with alprazolam can lead to dangerous side effects, including the possibility of an overdose.
This benzodiazepine based medication has been reported to cause withdrawal and sedation in new-born babies and should be avoided by expectant or breastfeeding women. In general, exposure to all benzodiazepine based medications should be avoided during the first trimester.
People who buy Xanax online in the UK should always read the product leaflet before consuming the medication.
This anxiety relief medication is also available as a generic medication which usually cost less, but in some cases, the full range of strengths or form are not always available and therefore offer less choice than the brand-name versions of alprazolam.
Alprazolam tablets are generally available in the UK in 0.5 mg, 1 mg and 2 mg tablets.
If an alprazolam dosage is missed or forgotten, patients should take the missed dose as soon as they remember. If it is almost time to take the next dose, patients should skip the missed dose and continue with the dosage schedule as normal.
The usual alprazolam dosage for patients with anxiety should start with a dose of 0.25 to 0.5 mg given three per day. This dose can be increased to get the maximum effect, but at intervals of 3 to 4 days, and should not be more than a daily dose of 4 mg, such as 4x1 mg.
The lowest possible effective dose should be used, and the need for continued treatment reassessed frequently. The risk of dependence may increase with dose and duration of treatment.
Medical professionals have found that the effective treatment of some panic disorders has required the use of this medication at doses greater than 4 mg per day. In a clinical study performed to find the efficacy of alprazolam in panic disorder, doses ranged from 1 mg to 10 mg per day.
The average alprazolam dosage given was around 5 to 6 mg per 24 hours, and of the 1700 patients who took part in the panic disorder development program, around 18% of patients received doses greater than 7 mg/day, including approximately 100 patients who received the maximum dose of greater than 9 mg/day.
As with anxiety disorders, treatment should be started at a low dose to minimize the risk of undesirable reactions in patients who may be sensitive alprazolam. The alprazolam dosage can be increased until a significant reduction in panic attacks or total eradication is accomplished, intolerance occurs, or the maximum recommended dose is attained.
A patient's alprazolam dosage should be reduced gradually when discontinuing therapy or when decreasing the daily dosage. Although clinical trials have established no strict rules or developed a specific discontinuation schedule, it is generally advised that the daily dosage should be decreased by no more than 0.5 mg every 3 days, but due to factors such as age, size, and weight, some patients may require an even slower dosage reduction.
Alprazolam is an effective treatment for anxiety and panic disorders when used correctly, but factors such as other medications and health conditions can affect how alprazolam works and how long it stays in the body.
This medication should be used only when needed. If it is used on a continuous basis, treatment usually does not exceed four weeks. The recommended dose for elderly patients and those with liver or kidney problems, is usually half a tablet (0.5 mg).
Patients should take care to follow the directions and read all medication guides in the product leaflet, and should never use this strong sedative in larger amounts, or for longer than six weeks unless prescribed by a doctor. Tell your doctor if you feel an increased urge to use more of this medicine.
Alprazolam is usually taken for no longer than 4 months to treat an anxiety disorder, and for no longer than 10 weeks to treat a panic disorder.
Anyone with an anxiety or panic disorder should work with their healthcare provider to develop the safest and most effective treatment program for them.
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Xanax is part of a class of medication called benzodiazepines. These medications are used to treat anxiety and panic disorder. Xanax works to treat anxiety by increasing the activity of the GABA neurotransmitter in the brain. GABA is responsible for producing feelings of calmness. When Xanax enhances GABA transmitters, feelings or relaxation and calmness are induced thus eliminating anxiety.
Yes. This medication treats panic disorder and nausea following chemotherapy. It can also induce sleep and treat anxiety conditions which are linked to co-morbid depression.
Users feel the effects of Xanax in under 60 minutes. The tablet reaches its peak concentration level in the body 1 to 2 hours after consumption.
There is no evidence to suggest that Xanax can affect a patient's overall fertility.
No, it cannot. The properties of this medication have a negative reaction to alcohol. Users are advised to stay clear of alcohol when taking this medication as it can cause decreased alertness, drowsiness and adverse effects.
Published: 20 February 2021
Review Due: February 2022